| Transactions |
| Date | Player | POS | Transaction |
|---|
| Oct 19, 2018 | Auden Tate | WR | pract. squad add |
| Oct 18, 2018 | Auden Tate | WR | cut |
| Oct 18, 2018 | KeiVarae Russell | CB | active/prac. squad |
| Oct 10, 2018 | Demetrious Cox | | pract. squad add |
| Oct 10, 2018 | Matt Lengel | TE | active/prac. squad |
| Oct 9, 2018 | Thomas Rawls | RB | cut |
| Oct 5, 2018 | Tyler Eifert | TE | on IR, broken right ankle |
| Oct 1, 2018 | Vontaze Burfict | LB | suspension lifted |
| Sep 28, 2018 | Tra Carson | RB | cut |
| Sep 26, 2018 | Adolphus Washington | DT | active/prac. squad |
| Sep 26, 2018 | Ryan Glasgow | DT | on IR, torn ACL |
| Sep 19, 2018 | Thomas Rawls | RB | signed |
| Sep 18, 2018 | Randy Bullock | K | re-signed, Two-year extension (through 2020) |
| Sep 12, 2018 | Matt Barkley | QB | cut |
| Sep 8, 2018 | Alex Erickson | WR | re-signed, Two-year extension (through 2020) |
| Sep 6, 2018 | Chris Okoye | DT | cut |
| Sep 6, 2018 | Josh Shaw | CB | cut |
| Sep 3, 2018 | Christian Hackenberg | QB | pract. squad add |
| Sep 3, 2018 | Davontae Harris | CB | on IR, knee |
| Sep 3, 2018 | Michael Johnson | DE | signed |
| Sep 2, 2018 | Andrew Brown | DT | pract. squad add |
| Sep 2, 2018 | Brad Lundblade | OL | pract. squad add |
| Sep 2, 2018 | C.J. Goodwin | DB | pract. squad add |
| Sep 2, 2018 | Chris Worley | LB | pract. squad add |
| Sep 2, 2018 | Jordan Franks | TE | pract. squad add |
| Sep 2, 2018 | KeiVarae Russell | CB | pract. squad add |
| Sep 2, 2018 | Kent Perkins | T | pract. squad add |
| Sep 2, 2018 | Kermit Whitfield | WR | pract. squad add |
| Sep 2, 2018 | Moritz Boehringer | TE | pract. squad add |
| Sep 2, 2018 | Quinton Flowers | RB | pract. squad add |
| Sep 1, 2018 | Andrew Brown | DT | cut |
| Sep 1, 2018 | Brad Lundblade | OL | cut |
| Sep 1, 2018 | Brandon Bell | LB | cut |
| Sep 1, 2018 | Brian Hill | RB | cut |
| Sep 1, 2018 | C.J. Goodwin | DB | cut |
| Sep 1, 2018 | Cethan Carter | FB | on IR, shoulder |
| Sep 1, 2018 | Chris Worley | LB | cut |
| Sep 1, 2018 | Devonte Boyd | WR | cut |
| Sep 1, 2018 | Eddy Wilson | DT | cut |
| Sep 1, 2018 | Jared Murphy | WR | cut |
| Sep 1, 2018 | Jonathan Brown | LB | cut |
| Sep 1, 2018 | Jordan Franks | TE | cut |
| Sep 1, 2018 | Junior Joseph | LB | cut |
| Sep 1, 2018 | Justin Murray | T | cut |
| Sep 1, 2018 | Ka'Raun White | WR | cut |
| Sep 1, 2018 | Kayaune Ross | WR | cut |
| Sep 1, 2018 | KeiVarae Russell | CB | cut |
| Sep 1, 2018 | Kent Perkins | T | cut |
| Sep 1, 2018 | Kermit Whitfield | WR | cut |
| Sep 1, 2018 | Logan Woodside | QB | cut |
| Sep 1, 2018 | Michael Johnson | DE | cut |
| Sep 1, 2018 | Moritz Boehringer | TE | cut |
| Sep 1, 2018 | Quinton Flowers | RB | cut |
| Sep 1, 2018 | Ryan Hewitt | TE | cut |
| Sep 1, 2018 | Simeyon Robinson | DL | cut |
| Sep 1, 2018 | T.J. Johnson | C | cut |
| Sep 1, 2018 | Trayvon Henderson | DB | on IR, knee |
| Sep 1, 2018 | Tyrice Beverette | DB | cut |
| Aug 31, 2018 | Jarveon Williams | RB | cut |
| Aug 30, 2018 | Darius Hillary | CB | cut |
| Aug 28, 2018 | Carlos Dunlap | DE | re-signed, Three-year extension (through 2021) |
| Aug 28, 2018 | Cory Helms | G | cut |
| Aug 28, 2018 | Darius Hillary | CB | signed |
| Aug 28, 2018 | Geno Atkins | DT | re-signed, Four-year extension (through 2022) |
| Aug 24, 2018 | Chris Baker | DT | cut |
| Aug 23, 2018 | Sojourn Shelton | CB | cut |
| Aug 19, 2018 | George Iloka | DB | cut |
| Aug 13, 2018 | Simeyon Robinson | DL | signed |
| Aug 10, 2018 | Austin Fleer | T | cut |
| Aug 10, 2018 | Ray Lawry | RB | cut |
| Aug 4, 2018 | C.J. Goodwin | DB | signed |
| Aug 4, 2018 | Cory Helms | G | signed |
| Aug 4, 2018 | Eddy Wilson | DT | acquired from waiver |
| Aug 4, 2018 | Kayaune Ross | WR | signed |
| Aug 4, 2018 | Rod Taylor | G | on IR, knee |
| Aug 2, 2018 | Brandon LaFell | WR | cut |
| Aug 2, 2018 | Ja'Von Rolland-Jones | DE | cut |
| July 26, 2018 | Jared Murphy | WR | signed |
| July 26, 2018 | Javarius Leamon | T | reserve/DNR |
| July 17, 2018 | Gaelin Elmore | DE | retired |
| June 21, 2018 | Malik Jefferson | LB | signed/draft choice, Four-year contract (through 2021) |
| June 21, 2018 | Sam Hubbard | DE | signed/draft choice, Four-year contract (through 2021) |
| May 21, 2018 | Billy Price | C | signed/draft choice, Four-year contract (fifth-year option) |
| May 14, 2018 | Auden Tate | WR | signed/draft choice, Four-year contract (through 2021) |
| May 14, 2018 | Brad Lundblade | OL | signed |
| May 14, 2018 | Chris Okoye | DT | signed |
| May 14, 2018 | Oni Omoile | G | cut |
| May 14, 2018 | Robenson Therezie | DB | cut |
| May 14, 2018 | Scott Orndoff | TE | cut |
| May 14, 2018 | Tyrice Beverette | DB | signed |
| May 12, 2018 | Darius Phillips | CB | signed/draft choice, Four-year contract (through 2021) |
| May 12, 2018 | Jessie Bates | FS | signed/draft choice, Four-year contract (through 2021) |
| May 12, 2018 | Mark Walton | RB | signed/draft choice, Four-year contract (through 2021) |
| May 11, 2018 | Andrew Brown | DT | signed/draft choice, Four-year contract (through 2021) |
| May 11, 2018 | Austin Fleer | T | signed |
| May 11, 2018 | Chris Worley | LB | signed |
| May 11, 2018 | Davontae Harris | CB | signed/draft choice, Four-year contract (through 2021) |
| May 11, 2018 | Devonte Boyd | WR | signed |
| May 11, 2018 | Gaelin Elmore | DE | signed |
| May 11, 2018 | Ja'Von Rolland-Jones | DE | signed |
| May 11, 2018 | Jordan Franks | TE | signed |
| May 11, 2018 | Junior Joseph | LB | signed |
| May 11, 2018 | Logan Woodside | QB | signed/draft choice, Four-year contract (through 2021) |
| May 11, 2018 | Quinton Flowers | RB | signed |
| May 11, 2018 | Ray Lawry | RB | signed |
| May 11, 2018 | Rod Taylor | G | signed/draft choice, Four-year contract (through 2021) |
| May 11, 2018 | Trayvon Henderson | DB | signed |
| May 8, 2018 | Ka'Raun White | WR | acquired from waiver |
| May 2, 2018 | Cedric Ogbuehi | T | team declines option, Fifth-year option on rookie contract |
| May 1, 2018 | Moritz Boehringer | TE | signed, International Player Pathway Program |
| Apr 30, 2018 | Carl Bradford | LB | cut |
| Apr 30, 2018 | Connor Harris | LB | cut |
